“ALLHAT,” Anithypertensive
and Lipid-Lowering Treatment to Prevent Heart Attack Trial
|
| |
|
National Heart Lung and Blood Institute (NHLBI),
U.S. National Institutes of Health (NIH) |
| |
Region 7 Principal Investigator |
| |
|
Richard Grimm, MD, PhD, MPH, Berman Center for Outcomes and Clinical
Research |
| |
Region 7 and Berman Center Coordinator |
| |
|
ALLHAT, conducted from 1994 to 2002, consisted of 2 trials: one
compared a diuretic with newer antihypertensive drugs to start
blood pressure-lowering treatment; the other compared a statin
drug to usual care. The study was the first one done exclusively
in patients with high blood pressure and involved over 10,000 participants,
making it the largest hypertension clinical trial ever conducted.
Findings indicated that less costly, traditional diuretics work
better than newer medicines to treat high blood pressure and prevent
some forms of heart disease. |
| |
|
The duration of the intervention and follow-up was an average of
6 years. There were 42,418 participants enrolled at approximately
600 office-based practice sites across the U.S., Puerto Rico, the
Virgin Islands, and in Canada. This study has concluded. |
| |
Role of the Berman Center |
| |
|
The Berman Center completed study recruitment and screening.
32 enrollees completed their study visits here; 97% of these of
participants completed the trial. |
| |
|
To find out more about ALLHAT, please visit the National Heart,
Lung, and Blood Institute’s fact
sheet on this study |
