||• Age ≥50 years (if female, post-menopausal)
• Prior heart attack, more than 6 weeks ago
• No prior chelation therapy within 5 years
• No hospitalization for heart failure within previous 6 months
• No cigarette smoking within previous 3 months
||Interested participants will attend a screening visit to determine
eligibility. The screening visit is about 90 minutes long. Eligible
participants will be randomized to one of the four study arms.
All participants will take pills that contain either high- or low-dose
vitamin/minerals, in three pills taken twice daily. In addition,
all participants will receive 40 intravenous (IV) infusions of
either chelation or placebo. The first 30 infusions will be given
weekly, and the last 10 infusions will be given every 2-8 weeks.
It may take up to 28 months to complete all the required infusions.
Each infusion visit could take up to five hours (3 hours for the
infusion plus other time for the medical staff to check recent
After the 40 infusion visits have been completed, Berman Center
research staff call participants every 3 months until the end of
the study to find out how they are doing and whether they have
had any heart problems since the last call. In addition, participants
will be asked to return for a Berman Center clinic visit each year
and at the end of the study. At each visit, participants are asked
questions about their medical condition and undergo a simple physical
||Contact the Berman Center Site Coordinator, Mary Perron, RN at